I mean, obviously? SSDs and HDDs randomly fail for all sorts of reasons beyond random bitflips, so properly working ECC isn't enough to guarantee your files are "fine". Even if you're using something like ZFS, it's possible for the one of the underlying drive to experience ECC errors, and have another drive fail before that can caught. If your parity factor is 1 or less (eg. RAIDz1), you'll also experience data loss.