Yes, and it actually works. I use something like htmx or fixi [1] for my frontends of side-projects. Alternatively, I could also use laravel livewire, I even argue you could use them for large-scale projects like ERP systems. I even re-build small parts of a large ERP system including the design system implemention using htmx. No need for react or similar things, if you know HTML and CSS well and are a bit disciplined.

But once you don't use ORMs or have a non-monolithic architecture, you need something to validate your schema.

[1] https://github.com/bigskysoftware/fixi