I have crippling migraines 4-6 times a year and I've had them forever. When it happens, I cannot handle light, cannot handle sound, I have a hard time thinking through the brain fog and I just want to stay in a quiet room with very low light waiting for it to pass which takes anywhere from 12 hours to 36 hours. I've lived in quite a few different countries both rural and city areas so it's not location dependent. I stay very hydrated so it's not the issue. Diet doesn't seem to change much either (although I do eat a bit too much sugar but my mom who has the same problem definitely doesn't). So, it's exhausting but I live with it and thank my lucky stars that it's only 4-6 times a year so it doesn't impact my work or life that much.
Ah yeah I can see the problem.
Apparently there is a potentially lasting effect with one dose. Maybe it's something you can vecation after. Or if the effect is actually there someday a medicine will be available.