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> and the uncertainty is the cause of the conflicting recommendations for or against boosters.

Imo it's more relevant that the majority of the human race is not even vaccinated twice. We have to decide, where we can safe more lives. Boosting the immune response in western countries, or giving vaccine to the poorer parts of the world.



Indeed. Almost everybody agrees that boosters probably reduce symptomatic infection and community spread. The real questions are:

1. Effect size

2. Relative effectiveness compared to more vaccinations in third world countries.




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