http://en.wikipedia.org/wiki/Universalis http://www.indie-rpgs.com/ramshead/
I suspect it would be incredibly cumbersome, but it's on my list of things to try.
http://nomic.info/perlnomic/ http://groups.google.com/group/ecmanomic/web/getting-started
There were a good number of people playing online versions like Ackanomic and Internomic.
Great game with lots of high-level cleverness.
http://en.wikipedia.org/wiki/Universalis http://www.indie-rpgs.com/ramshead/