Redundant! Every UPC barcode has a 6 on the beginning, middle, and end. If you've got the mark of the Beast you may as well get Beast Bux.

I've never seen reliable data suggesting that sucralose is harmful. Could be wrong. If you wouldn't mind giving sources, that would be helpful. Or is it just a personal sensitivity? Don't mean to pry. I'm just curious about the issue.

It just tastes disgusting to me and ruins anything it's in. I have a long history of avoiding certain foods/ingredients (e.g. onions) so I was already somewhat used to reading ingredient labels before deciding if I should consume things and being a bit picky generally.

From another angle, I think it's quite shady and dishonest of them to mix artificial sweeteners into non-diet drinks and not make it clear. If someone sells sugar free drinks and not-sugar-free drinks, they shouldn't both have sucralose.

I have heard certain artificial sweeteners kill your gut bacteria, but honestly I don't care much about that. If I heard that about sugar, I wouldn't start avoiding sugar.

That makes total sense to me. I've avoided onions most of my life. More saliently, I agree that it's off-putting to hide the inclusion of artificial sweeteners. Thanks for your response--I appreciate it.

One of the Gnossiennes was in Spider Forest as well -- great Korean psychological horror.

I think the other commenter is right...you're thinking of DVD-R vs DVD+R, possibly even DVD-RW and DVD+RW.

Based on the specs listed, OP was in college just before me or may have overlapped. The big gold CD-R stacks (you could bur in jewel cases, on spindles, or just gross stacks which were nice and cheap) were a huge thing with my group (who encoded to FLAC & MP3 -V0 and burned audio CDs relentlessly. We felt we were archiving our liberal arts college music library and radio library for the future! Who knows. Some of that "future" is still backed up and on hard disks, and I should migrate them to SSD or tape just on principle.

At that point CD-R were cheaper than CD-RWs, and because most archiving/distributing didn't require rewriting (not return-on-investment wise anyway), we just shared programs on CD-R as well. In some ways it was a beautiful technology! Particularly fidelity to a spec everyone tried to bend and break for a profit angle, when honestly, there was no point for many of us using CD-R

Is that really what "wow" means here? I took it more as "wow, I've been around forever / I must be old now" or something similarly tame.

Are you in the black as a household overall?

We aren't yet. Our projection is that we will be in 5-7 years. I'm turning forty soon.

Just to give you an anchor point.

What does “in the black” mean at a household level? Total assets minus loan balances being positive?

Sorry, yes. I was thinking net worth > 0.

Ah, I was wondering too but my reply button was gone, yes I would say we’ll be net > 0 around the same time as you age wise. If we hadn’t had to renovate a 60s property we’d possibly be there already but UK housing stock needs work sadly.

Does home price count as an asset in this "in the black" calculation?

Same here, but we are in a very similar boat in our voyage through socioeconomic statuses (though I'm in Ohio River Valley US). I may be fooled by the discourse that [Xennials/Oregon Trail gen/Gen Y/Elder Millennials], but we supposedly saved more, delayed gratification, planned more, and worked more than even Gen Z (who, don't get me wrong, have it worse because of undercompensation vs purchasing power and sheer hopelessness).

I doubt we're typical, is my point.

I feel you. What's worse: amyloid aggregates aren't fraud either, but certain ones are more conducive to fraud, and the fraudsters have been loudly denounced.

There is absolutely no question--none at all--that amyloid plaques are a key feature of Alzheimer disease, that they are neurotoxic, and that they fit within a number of mechanistic pathways contributing to dementia (which is the broad clinical phenotype).

Interestingly enough, the actual results of the lecanemab (Leqembi) trial is that those on drug had overall 17 months longer in the mild cognitive impairment / mild dementia range before declining to the moderate dementia range. It doesn't stop the disease, but it does measurably slow its course, and that makes a huge difference to families. Whether the linked author can accept that progress is mostly incremental and not wholly satisfying is, I don't know...his problem, but it is rapidly becoming our problem as dementia scientists.

But people love a conspiracy.

Got to pay someone to do the catching. We all do these reviews for nothing! Manuscript peer-reviews, and yes, even the major NIH study sections that review numerous grants every submission cycle.

I agree that the toothpaste is out of the tube here. But do the mods have to fix the reddit community? If HN gets out of hand, is that dang's fault?

For most of us it's a thankless job full of many uncompensated and thankless tasks, but we do it for any number of reasons. Most academic scientists I meet are capable and (mostly) driven by a desire to uncover knowledge.

Yes, these are good questions. I don't know how to fix it. But I do worry that if it isn't fixed, it may kill the field.

I appreciate the moral support from someone on the private research side. Politics aside, we all tend to value the common goal of improving population health, even if egos are tempted by perverse incentives.