One of the big problems with anesthesia is balancing respiratory depression while medicating the patient enough to manage the symptoms. Fentanyl is used in anesthesia and it causes respiratory depression.
A strong pain medication that doesn't slow or stop breathing would significantly improve the safety of anesthesia.
I wonder if this modification brings it closer to the mitragynine from kratom, which has opiate like pain dulling effects with very minor or no effect on breathing.
I hope so because the administration is looking to really fuck over medical research by making the 7-OH stuff a schedule 1 narcotic, when it has so much potential for improving anesthesia and pain management by removing respiratory depression from the pain killing element of the anesthetic cocktail.
My understanding is that mitragynine is an mu-opioid partial agonist which limits its impact even in high doses. This is sort of in the same realm as Buprenorphine. Google claims it also doesn't recruit beta-arrestin but admittedly I'm out of my depth here. Presumably this proposed fentanyl replacement is still a full mu-opioid agonist for efficacy.
Lotus root is pretty common. A crunchy tuber that keeps its texture after cooking, bland taste, unique visual appeal. I threw some in the last pot of bean chili my family made, and the kids liked it.
Seeing my neighbors gathering ginkgo nuts made me curious enough to try them, and I waded right in without understanding the risks! TLDR— they're not a great food source. It's yet another one of those cases where you have to wonder what "delicacy" means.
The actual fruit (looks like a rotten plum, smells terrible) has ginkgolic acids which cause contact dermatitis (think poison ivy).
Then the nuts themselves contain Ginkgotoxin, which interferes with your B6, screwing up your nervous system and causing seizures. Cooking reduces but does not eliminate Ginkgotoxin.
I only ate one, and ate it raw. It was a delightful texture, but tasted like chewing random plant matter. Like leaves from a tree. Was maybe half a cubic centimeter of matter. Escaped any ill effects.
According to my research, kids can have seizures from as few as 10 nuts, which would probably be like 1.5 spoonfuls if you mashed them up. The guidelines I found don't seem very scientific but supposedly a kid can safely handle 3-5 nuts over the course of a day, and an adult could handle 5-10. So it doesn't seem like there is a good margin of safety.
Overall a real risk to health for an insignificant amount of food that doesn't taste special. But a nice texture.
In university, one year, our building started smelling like there had been a sewage overflow. Pretty soon, everything around started smelling like this - the stores, restaurants, cinema, etc. in central campus was stinking. It was soon found out that the decorative Ginko trees planted in the central part of campus were fruiting (probably for the first time since planting) and the fruit was getting crushed underfoot and carried everywhere. The smell took a few weeks to go away.
The roasted or cooked nut of the ginkgo tastes good and is filling. Not something to eat in volume anyways. You'd probably quit before any toxicity manifests.
The fruit looks appetizing and at most smells a little funky when there are tons of them around a female tree.
I have always known it's inedible to humans so I have never tried but it could taste like custard given its color. Presumably whatever used to disperse it could eat it.
Other coniferous arils are tasty and sweet like yew for example even though the nut is supposed to be very poisonous.
Too many people think your life is a binary 'living or dead' when thats not the case at all. I didn't even understand it fully till I was hit by a car.
I'm not disagreeing with your overall take, but Tesla and other EV manufacturers have released the same model of vehicle with different battery technologies at different times. Only saying that dropping 4680 production isn't conclusive proof itself.
One of the big problems with anesthesia is balancing respiratory depression while medicating the patient enough to manage the symptoms. Fentanyl is used in anesthesia and it causes respiratory depression.
A strong pain medication that doesn't slow or stop breathing would significantly improve the safety of anesthesia.
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