It seems like the average consumer of diet sweeteners is already likely to be overweight, diabetic, or have other ailments. This article seems highly sensationalized. For the average person, the risk of sugar impacting blood glucose levels seems far riskier than any side effect of a NSS

As a former twitter entertainer once said, "I have never seen a thin person drinking Diet Coke."

I suppose we could do a nation-wide experiment by insisting that the sugar water vendors use only NSS for a year; but that would probably result in the overthrow of the government.

The fattest person I ever worked with used to drink 4-8 litres of diet coke a day. When I met him again two years later, his weight was normal. Asked how he did it, he just stopped drinking the diet coke.

NNSs trigger the same insulin/fat storage mechanism as sugar, but they arent absorbed, and stay on the blood longer, leading to insulin resistance.

Also interested to see if there's any proof of this. I know, anecdotally as an obese man, that whether I cut out diet soda or not doesn't seem to make a difference. Maybe I'm not doing it for long enough?

Are you drinking 4-8 litres a day?

Nowhere near that much.

Good. The dose makes the poison.

Please point us to some science about this, because of that is true, it’s a pretty big deal.

There's lots. Here's one that tested sugar+sweetener, note the decrease in insulin clearance when sweeteners are consumed, vs just sugar:

sucralose ingestion caused 1) a greater incremental increase in peak plasma glucose concentrations (4.2 ± 0.2 vs. 4.8 ± 0.3 mmol/L; P = 0.03), 2) a 20 ± 8% greater incremental increase in insulin area under the curve (AUC) (P < 0.03), 3) a 22 ± 7% greater peak insulin secretion rate (P < 0.02), 4) a 7 ± 4% decrease in insulin clearance (P = 0.04), and 5) a 23 ± 20% decrease in SI (P = 0.01).

https://diabetesjournals.org/care/article/36/9/2530/37872/Su...

It's anecdata but I've seen similar - however, it could also be explained by "not taking weight loss seriously if all you do is switch to gallons of diet drink".

And for lots of sodas, caffeine plays, too. It's hard to factor out the various issues that could also be present.

That tweet doesn't reflect my experience at all actually, in Europe at least. I know it's an anecdote but I know many fit people that drink frequently Diet Coke or Coke Zero. Is this a US thing?

Coke Zero is much more common as an Everyman drink in Europe apparently, perhaps because of less sugar insensitivity.

In the USA a large size combo meal with a diet coke coming in at 1500+ calories is a meme based in reality.

> As a former twitter entertainer once said, "I have never seen a thin person drinking Diet Coke."

There's a lot he hasn't seen in this world. Doesn't mean those things don't happen.

Yeah, and also not even an insightful joke. I mean, isn't Taylor Swift, notable thin pretty human, a famous Diet Coke fan? That's just the first person who comes to mind. Also half the people I know, as well.

From my understanding the evidence of gut biome modification is weak, and would require a large volume consumption. Some NSS will cause temporary stomach upset if it’s your first few times consuming them. But I don’t think this has any long term impacts on gut health. Some NSS are healthy for your oral micro biome (erythritol for sure).

I was curious about this as well. It seems like arbitrary short names were “premium” without any value in their meaning.

Well, .dev domain has HSTS enabled to all subdomains. And there won't be even a hit to port 80 - it goes straight HTTPS by browser because of preload list. So you can't have non-HTTPS site on .dev domain visited by a browser. Thats some value.

You can serve anti-HSTS headers if you really want to serve HTTP, but you'll need to serve HTTPS for the initial page loads.

I was able to pick up https://badday.mov/ for regular price. :D

I put this in my ZSH profile.

  function cheat() {
      curl cht.sh/$1
  }

I have a similar setup:

    function cheat() {
        cheatcommand=$1
        shift;
        IFS='+'
        str="$*"
        if [ "$#" -eq 0 ]; then
            curl cht.sh/$cheatcommand
        else
            curl cht.sh/$cheatcommand/$str
        fi
    }

Suggesting long term SERM use in replacement of a bio identical testosterone does not seem like the brightest idea. There have been reports of blurred vision, floaters in the eyes, and more (look on pubmed under just about any SERM, but specifically clomid).

In my opinion it would be much safer to suggest recombinant FSH and LH. The brain testes axis seems to have the least amount of atrophy over time from anecdotal experiences of those online and in a few case reports. I do not think HCG should be used long term due to the non-bio identical nature, but it is a good short term LH mimic if my memory serves me correctly. Would be a great addition to a TRT protocol.

Research indicates blurred vision happens but is rare.

I thought LH/FSH is usually increased using HCG injections? Is there an oral route for LH//FSH? One of the benefits of clomiphene is it’s orally administered so no complex refrigeration / injectable requirements.

https://pubmed.ncbi.nlm.nih.gov/31216250/

Genuine question, how is a browser tab different than thunderbird? Besides storing a local copy of mail (which is obviously a huge win), I don't see a big difference. If anything I like the web UI better.

However, for my uses I simply installed proton bridge + apple mail. It just works with all email services I use.

> Genuine question, how is a browser tab different than thunderbird?

Different protocols for one thing - HTTP vs IMAP and/or POP/SMTP.

Each webmail app does things it’s own way. Webmail conflates the app and the protocol and the provider. Some people prefer to have mail from different providers in a unified app.

Currently I forward all my iCloud mail to my protonmail. Not sure if the aliases will stick around after cancelling a subscription however.

I must have gotten catfished

Do you own the url theneo.com? I noticed the documentation for the demo [0] uses this url, but the url doesn't redirect to your site.

[0] - https://app.theneo.io/demo/theneo/theneo_api_reference

Hey @adamheam, could you please let us know where you see that? you can send us feedback through intercom.

curious